🌞 New Alzheimer's Treatment?

Daily Upsider - Saturday, February 17th, 2024

Saturday, February 17th, 2024

Good Morning! 🌞 

Did you know that there are More Trees on Earth Than Stars in the Milky Way?

It’s estimated that Earth is home to over 3 trillion trees. In comparison, the Milky Way galaxy has between 100-400 billion stars. This fact honestly surprised me as I would have guessed there to be a lot more stars in our galaxy than trees…

Today’s Upside

Culture

Americans Are Optimistic About The Future

By Jon Tyson


The U.S. is often seen as a hopeful nation, and recent survey results support this perception. The data reveals that 82% of Americans maintain an optimistic outlook on their personal futures, with an even larger majority—85%—expressing hope for their family's future.

The 2024 report, "Hope in America: Visions of the Future," conducted by the Human Flourishing Lab, a program from the Archbridge Institute, derives insights from interviews with over 2,000 U.S. adults, offering a nationally-representative perspective.

Clay Routledge, the Director of the Human Flourishing Lab and co-author of the report, points out the role of hope in individual and societal flourishing. Mental health serves as a key indicator, with 82% of respondents perceiving good mental health expressing more hope.

Routledge acknowledges the enduring presence of hope in America despite debates and divisions, underscoring the importance of monitoring mental health. The survey, conducted between October 5-9, 2023, amid challenging global events, discloses that 56% of respondents maintain hope for the future of the entire country.

The report underscores the broader benefits of a hopeful mindset, extending beyond personal achievement. It suggests that hopeful individuals can inspire others and contribute to community engagement, fostering collective efforts to address societal challenges.

To think that just 2 years ago, we were in the midst of a pandemic that was dividing the country, we’ve come a long way since then…

Science

Artemis IV: Establishing the Gateway to Mars (Part 4 of 5)

Artemis 4's projected flightpath | Source: NASA 

Introducing the Lunar Gateway

Artemis IV will have 4 crew members and represents a critical step in the Artemis program, focused on the deployment of the International Habitation module (I-Hab) to the Lunar Gateway. The Gateway is a new space station that will serve as a multi-purpose outpost orbiting the Moon. This mission, targeted for 2027, is instrumental in establishing the Lunar Gateway with its pivotal role in achieving a sustainable human presence in lunar orbit.

The Importance of the Lunar Gateway

The Lunar Gateway is an innovative space station project that will orbit the Moon, providing living quarters, research facilities, and support for both robotic and human missions. The I-Hab module, is the part of the Gateway that will offer the living and working space for astronauts, enabling longer missions and serving as a hub for science, exploration, and partnerships across nations. 

Unlike the continuously inhabited International Space Station, the Gateway will be occupied intermittently, serving as a vital hub for deep space exploration. The addition of the I-Hab module, with its living and research spaces, is crucial for extending human presence in lunar orbit and beyond.

I find the idea of Astronauts living in a space station so far away from earth both incredibly fascinating while also very frightening. It will be amazing to hear from the astronauts what that experience is like!

Innovation

Promising Synapse Repair for Alzheimer’s

Brain memory neurons activated during memory formation – UIC image

A new study from the Buck Institute brings a different angle to tackling memory problems linked with Alzheimer's disease. Instead of going for the usual methods that target harmful tau proteins, the researchers look into the potential of a natural protein called KIBRA, which is found in the kidneys and the brain.

In people with Alzheimer's, having lower levels of KIBRA affects how synapses (connections between brain cells) work and memory. The researchers make progress by creating a working version of KIBRA, which successfully improves memory in lab mice mimicking Alzheimer's.

An interesting find is a strong connection between the levels of KIBRA in the fluid around the brain and the seriousness of dementia. This discovery suggests that KIBRA could be a useful marker for diagnosing, planning treatment, and tracking the progression of the disease.

Surprisingly, KIBRA can restore memory in mice without directly dealing with the harmful tau proteins. Kristeen Pareja-Navarro, co-first author of the study, says, “Our work suggests that KIBRA could be used to improve memory even though the harmful protein causing the damage is still there.”

This different approach, centering on KIBRA, could be a promising way to effectively treat Alzheimer's. While traditional methods struggle with the problem of harmful tau buildup, KIBRA offers a unique strategy to address memory problems and potentially change how we treat Alzheimer's patients.

World News

Celtic Water Burial Hoard Found in Polish Lake

A. Piasecka / Antiquity Publications Ltd.

A collection of bronze jewelry and human remains was discovered in a dried-up lakebed in Poland, shedding light on the ceremonial practices of the ancient Chełmno group from the Late Bronze/Early Iron Age Lusatian culture. The findings, including 550 artifacts and human remains, were uncovered at Papowo Biskupie, marking a significant testimony to ritual activities during the Lusatian period.

The artifacts, dating between 1,000 and 750 BCE, consisted of arm rings, necklaces, trinkets, and a Mediterranean glass bead, suggesting possible engagement in European trade. The burial of these items after the bodies indicate a cultural shift coinciding with increased metal use. The Chełmno group, initially less involved in metalwork, may have adopted these practices later. The site's significance lies in its divergence from common Celtic bog burials, potentially signifying a transition from human sacrifice to metal offerings during the cultural evolution of the Lusatian elites towards Hallstatt culture. The inclusion of female ornaments and horse-related accessories aligns with a broader pattern in Hallstatt finds, hinting at the role of women in votive depositions.

Not sure how to spend the weekend? Too tired to come up with ideas? Here are some suggestions for activities you might want to try !

Outdoor Adventures:

  • Hike a nearby trail.

  • Go for a bike ride.

  • Explore a local park.

Relaxation and Self-Care:

  • Have a DIY spa day at home.

  • Read a book or start a new one.

  • Practice meditation or yoga.

  • Take a nap or enjoy a quiet day.

Food and Cooking:

  • Try a new restaurant or cuisine.

  • Cook a meal you’ve never cooked before

  • Host a potluck with friends.

  • Attend a cooking class.

Entertainment:

  • Host a movie night

  • Attend a local event or concert.

  • Host a game night with friends.

Fitness and Recreation:

  • Join a fitness class or sports activity.

  • Go to a local (indoor) swimming pool

  • Try a new workout routine.

  • Play pickle ball!

Travel and Day Trips:

  • Take a day trip to a nearby town you haven’t been to.

  • Visit a zoo or aquarium.

  • Plan a weekend getaway.

Mind Stretchers

⁉️ 

What can be stolen, mistaken, or altered, yet never leaves you your entire life?

Answers to yesterday’s Mind Stretchers:
It’s Fridayy! 😛 

Eugene Hostetler got the correct answer in first!

Be the first to send us the correct answer for today’s mind stretcher for a shout-out with the answer tomorrow. Just send us the answer and your name to [email protected] or reply to the email.

From the Community

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